Enrichr MCP Server

Gene set enrichment analysis using Enrichr API with multi-library support

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  • Made byTianqi Tang
  • AddedMarch 2026

A Model Context Protocol (MCP) server that provides gene set enrichment analysis using the Enrichr API. This server supports all available gene set libraries from Enrichr and returns only statistically significant results (adjusted p < 0.05) for LLM tools to interpret.

Features:

- Multi-Library Enrichment Analysis: Query multiple Enrichr libraries simultaneously

- Comprehensive Library Support: Access to hundreds of gene set libraries including GO, pathways, diseases, tissues, drugs

- GO Enrichment Analysis: Specialized tool for GO Biological Process enrichment analysis

- Configurable output formats: detailed, compact, or minimal

- Export results to TSV files

Tools

  • enrichr_analysis
  • suggest_libraries

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