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Connectors give Claude access to external data sources during an analysis. Skills are written instructions Claude loads when relevant, covering how to run a method, which tools to use, and what to verify. Both are managed in Settings and apply across all projects. Claude Science includes Featured connectors to public life-sciences databases. All are on by default and can be turned off individually in Settings > Connectors. Featured connectors are read-only and don’t require an account or key. Some underlying databases have non-commercial or attribution terms; review each source’s license for your use case.
ConnectorSources
GenomesEnsembl (incl. VEP), UCSC
Genes & OntologiesMyGene, UniProt, GO, Reactome, OLS
VariantsgnomAD, ClinVar, dbSNP
Human GeneticsGWAS Catalog, eQTL Catalogue, FinnGen, BioBank Japan
Clinical GenomicsClinGen, CIViC, Open Targets
ExpressionGTEx
RegulationENCODE, JASPAR, UniBind
Protein AnnotationInterPro, Pfam, Human Protein Atlas, STRING
Structures & InteractionsPDB, AlphaFold, EMDB, Complex Portal, IntAct
RNARfam
Omics ArchivesGEO, ArrayExpress, PRIDE, MGnify, MetaboLights
Cancer ModelscBioPortal
ChemistryPubChem, ChEBI, Rhea, BindingDB
Drug RegulatoryFDA drug data, openFDA
Literature GraphOpenAlex, arXiv
Research ResourcesGrants.gov, Antibody Registry
Additional Featured connectors: BioMart, CellGuide (CELLxGENE cell types), ZINC (purchasable chemical space), and Ketcher Chemistry (2D molecule sketcher). Four Directory connectors are available from the connector directory and are accessible in Claude Science and other Claude products: PubMed, Clinical Trials, ChEMBL, and bioRxiv. On Team and Enterprise plans, directory connectors appear only after an admin adds them. By choosing to enable connectors, you authorize Claude to use the optional enabled resources on your behalf and confirm you have the necessary rights and licenses. These resources and content they reach may be subject to third-party terms (viewable in Settings), and you are solely responsible for compliance.

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Using connectors

Name a source in your request, or describe what you need and Claude chooses from available connector tools. Connector queries appear in the conversation as expandable code steps. Featured connectors you’ve previously enabled run without a permission card. Connectors you add yourself prompt for approval per tool, with Once, This conversation, This project, or Global scope. The databases behind Featured connectors are on the network allowlist in groups under Settings > Network. Turning off a group disables the connectors that depend on it.

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Skills

Settings > Skills lists the skills Claude can load. Featured science skills include literature review, indication dossier, and model-specific skills for AlphaFold2, Boltz-2, Chai-1, ESMFold2, OpenFold3, ProteinMPNN (with LigandMPNN and SolubleMPNN), DiffDock, ESM-2, Evo 2, Borzoi, scGPT, and scvi-tools. Claude loads a skill automatically when the work calls for it. Type / in the composer to open the skill picker and insert one explicitly. Add skill lets you create your own via Chat with Claude, Write from scratch, Upload a skill, or Import from GitHub. You can also ask Claude to distill a workflow from an existing session into a skill.